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Efficacy of Magseed Localization for Non-palpable Breast Lesions: A Systematic Review and Meta-analysis
Lamees M Al Darwashi1, May Y Hajeir1, Rashad M Abdelrahman2
1School of Medicine, University of Nicosia, Nicosia, Cyprus.
Background/Aim:
Accurate preoperative localization is essential for successful breast-conserving surgery on non-palpable breast lesions. In recent years, Magseed has emerged as a non-wired localization approach with promising outcomes due to its flexibility and precision. This meta-analysis aimed to evaluate the efficacy and safety of Magseed localization on non-palpable breast lesions.
Materials And Methods:
Ovid MEDLINE, CINAHL, Ovid EMBASE, and The Cochrane Library were searched from inception to February 2025, following PRISMA guidelines. The pooled mean and proportions were analyzed using a random-effects model. The review was registered with PROSPERO (CRD420250654940).
Results:
From 958 studies screened, 16 studies involving 2,117 patients and 2,176 Magseeds were included. The overall rate of positive margins was 7.6% [95% confidence interval (CI)=0.04, 0.11, I2=88%], and the re-excision rate was 8.2% (95%CI=0.05, 0.12, I2=87%). The overall complication rate was 0.6% (95%CI=0.001, 0.011, I2=7%). The success rate for Magseed placement was 99.3% (95%CI=0.987, 0.998, I2=1%), the migration-related failure was 0.6% (95%CI=0.001, 0.011, I2=0%), and the retrieval success rate was 99.6% (95%CI=0.992, 0.999, I2=0%). The mean operative time was 61.4 min (95%CI=55.9, 66.9, I2=98%).
Conclusion:
Magseed appears to be a safe and effective technique for the preoperative localization of selected non-palpable breast lesions. Nonetheless, further studies based on breast density, size, and depth are required to investigate the feasibility of preoperative Magseed localization for patients with non-palpable breast lesions.
