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CD70-Targeted Immuno-PET/CT for Detecting Heterogeneous CD70 Expression in Lymphomas: A Pilot Clinical Study
Xiaona Zheng1, You Zhang2, Jianchen Fang3
1Department of Hematology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
CD70-targeted immuno-PET/CT imaging shows promise for lymphoma diagnosis and treatment monitoring. This technique effectively visualizes CD70 expression, aiding in the development of targeted therapies.
Area of Science:
- Oncology
- Nuclear Medicine
- Immunotherapy
Background:
- CD70 is a potential therapeutic target in lymphoma.
- Expression patterns and diagnostic utility of CD70-targeted immuno-PET/CT in lymphoma are not well-defined.
Purpose of the Study:
- To investigate CD70 expression in lymphoma patients.
- To evaluate the diagnostic performance of CD70-targeted immuno-PET/CT in lymphoma.
Main Methods:
- Analyzed CD70 expression in 154 lymphoma specimens.
- Conducted a clinical trial (NCT06852638) involving 20 lymphoma patients undergoing CD70-targeted immuno-PET/CT.
- Compared diagnostic performance with [18F]FDG PET/CT.
Main Results:
- CD70 was expressed in 63% of lymphoma specimens, with higher expression in older patients.
- CD70-targeted immuno-PET/CT demonstrated significant tracer uptake in lymphoma lesions, correlating well with CD70 expression.
- The technique showed noninferior diagnostic performance to [18F]FDG PET/CT, improving detection of intracranial lesions and monitoring therapeutic response.
Conclusions:
- CD70-targeted immuno-PET/CT is effective in visualizing CD70 expression in lymphoma.
- This imaging modality holds potential as a valuable tool for guiding CD70-targeted therapies and improving lymphoma management.
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