SERUM FERRITIN CONTENT AND INCIDENCE AND TYPE OF INFECTIOUS AND INFLAMMATORY COMPLICATIONS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA, RESIDING IN RADIOLOGICALLY CONTAMINATED TERRITORIES OF UKRAINE AFTER THE ChNPP ACCIDENT
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View abstract on PubMed
Summary
This summary is machine-generated.High serum ferritin (SF) levels in children with acute lymphoblastic leukemia (ALL) correlate with increased infectious complications and mortality. Early diagnosis and preventive measures for iron overload are crucial for improving outcomes in pediatric ALL patients.
Area Of Science
- Pediatric Oncology
- Hematology
- Environmental Medicine
Background
- Children residing in radiologically contaminated territories (RCT) after the ChNPP accident are at increased risk.
- Acute lymphoblastic leukemia (ALL) is a significant pediatric cancer requiring comprehensive management.
- Serum ferritin (SF) levels may indicate iron overload and influence disease progression and complications.
Purpose Of The Study
- To evaluate the frequency and types of bacterial and fungal complications in pediatric ALL patients from RCT.
- To assess the impact of serum ferritin (SF) levels on the outcomes of pediatric ALL.
- To analyze the relationship between SF content, infectious complications, and mortality in pediatric ALL.
Main Methods
- A 15-year survey of 146 pediatric ALL patients residing in RCT of Ukraine.
- ALL diagnosis and classification based on FAB criteria and immunophenotyping.
- Assessment of infectious, fungal, and toxic complications, and mortality rates, correlated with SF levels.
- Statistical analysis including Student's t-test, Spearman's correlation, and Chi-squared test.
Main Results
- Increased SF levels (above 200 ng/ml) were associated with higher incidence of sepsis and anal area infections.
- SF levels above 500 ng/ml correlated with complicated pneumonia and increased systemic toxic effects post-chemotherapy.
- Mortality rates nearly doubled in children with SF levels above 500 ng/ml, particularly in pro-B ALL and T-ALL variants.
- Iron overload was linked to poorer outcomes in common ALL and T-ALL subtypes.
Conclusions
- Elevated serum ferritin (iron excess) significantly impacts the incidence and type of infectious complications in pediatric ALL.
- Iron overload adversely affects the outcome of ALL in children, necessitating timely diagnosis and intervention.
- Preventive strategies targeting iron overload are essential for improving the management and prognosis of pediatric ALL.
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