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The role of DNASE1L3 in systemic lupus erythematosus: from pathogenesis to clinical implications

Xiaohan Liu1, Yikai Yu2, Shaozhe Cai3

  • 1Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Clinical and Experimental Medicine
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PubMed
Abstract

No abstract available in PubMed .

Keywords:
Cell-free DNADNASE1L3Interferon pathwaySystemic lupus erythematosus

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Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
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