Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Cerebral Hemispheres01:05

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
Lateralization01:28

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
Language and Cognition01:27

Language and Cognition

Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
Learning Disabilities01:25

Learning Disabilities

Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A lightweight network for segmenting tree-like structures in medical images.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society·2026
Same author

Matrix Stiffness Directs Stemness Signatures in Breast Cancer.

Advanced healthcare materials·2026
Same author

HSP47 is a potential dual cell target and prognostic factor in pancreatic cancer.

Oncogene·2026
Same author

Multimodal animal health monitoring in extensive livestock production systems.

Frontiers in veterinary science·2026
Same author

Cell segmentation in microscopy images using a SAM-based U-Net architecture and a novel dataset.

Computer methods and programs in biomedicine·2026
Same author

OCT-based optic neuropathy diagnosis using explainable and privacy-preserving machine learning.

Scientific reports·2026
Same journal

A Droplet-Microarray Platform for Multiplex Profiling of Breast Cancer Exosome Subtypes in Patients' Blood Plasma Samples.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Material-Dependent Functionalization of CVD-Grown TMDC Monolayers Probed by Vibrational Nanospectroscopy.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

BandGap Modulated Charge Gating of Semiconductor Coatings Stabilizes Zinc Metal Anodes.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

For High Capacity: Upcycling of Spent Graphite Catalytic via Precisely Tailoring Water-Gas Reaction.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Electronic Engineering of Donor-Acceptor Covalent Organic Frameworks via Fluorine Substitution for Efficient Solar Hydrogen Production.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Correction to: "A Gold Nanocage/Cluster Hybrid Structure for Whole-Body Multispectral Optoacoustic Tomography Imaging, EGFR Inhibitor Delivery, and Photothermal Therapy".

Small (Weinheim an der Bergstrasse, Germany)·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy
10:24

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy

Published on: February 21, 2013

13.5K

Decoding Endothelial Glycocalyx-Nanoparticle Interactions via a Systematic Polymeric Nanoparticle Library and

James Paoloni1, Miriam Jackson1, Elvis Pandzic2

  • 1School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia.

Small (Weinheim an Der Bergstrasse, Germany)
|December 31, 2025
PubMed
Summary
This summary is machine-generated.

Nanoparticle surface charge significantly impacts cellular interactions and toxicity more than size. A mature cell glycocalyx can protect cells from cationic nanoparticles, influencing drug delivery strategies.

Keywords:
drug deliveryendotheliumglycocalyxhigh‐throughput polymer librarynanoparticle

More Related Videos

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

16.5K
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

13.0K

Related Experiment Videos

Last Updated: Jun 17, 2026

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy
10:24

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy

Published on: February 21, 2013

13.5K
Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

16.5K
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

13.0K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cell Biology

Background:

  • Optimizing nanoparticle physicochemical properties is crucial for effective drug delivery.
  • Understanding nanoparticle interactions with cells requires systematic investigation.

Purpose of the Study:

  • To synthesize and characterize a library of polymeric nanoparticles varying in size and charge.
  • To evaluate the impact of nanoparticle properties on cellular interactions, including cytotoxicity and uptake.
  • To investigate the role of the cell glycocalyx in modulating these interactions.

Main Methods:

  • High-throughput synthesis of 42 polymeric nanoparticles using RAFT polymerization and PISA.
  • Characterization of nanoparticle cytotoxicity and uptake in endothelial cells with immature/mature glycocalyces.
  • Semi-automated imaging and machine learning for single-cell nanoparticle uptake quantification.
  • Assessment of protein corona formation and its effect on nanoparticle properties.

Main Results:

  • Surface charge was a more dominant factor than hydrodynamic diameter in determining nanoparticle cytotoxicity and cellular uptake.
  • Cationic nanoparticles showed higher toxicity and uptake, but cells with mature glycocalyces exhibited greater tolerance and uptake.
  • The cell glycocalyx plays a protective and regulatory role in nanoparticle interactions.
  • Protein corona formation altered nanoparticle surface charge and cellular interactions.

Conclusions:

  • Nanoparticle surface charge is a critical design parameter for drug delivery.
  • The cellular environment, particularly the glycocalyx, significantly influences nanoparticle behavior.
  • Scalable analytical methods are essential for optimizing nanoparticle formulations for targeted delivery.