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Updated: Jan 7, 2026
09:43
Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
Published on: August 1, 2025
685
Proteoglycans in Prostate Cancer Progression and Therapy Resistance.
1Laboratory for Epigenomics, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
Medicina (Kaunas, Lithuania)
|December 31, 2025
Summary
Proteoglycans (PGs) within the tumor microenvironment (TME) significantly influence prostate cancer progression. This review details their complex roles, impacting both cancer growth and therapy resistance.
Area of Science:
- Oncology
- Biochemistry
- Cell Biology
Background:
- The extracellular matrix (ECM) is crucial in the tumor microenvironment (TME), supporting cancer and stromal cells.
- Proteoglycans (PGs), key ECM components, possess diverse structures and functions vital for cellular processes.
- PGs are secreted by both cancer and stromal cells, adding complexity to TME interactions.
Purpose of the Study:
- To review the multifaceted roles of proteoglycans (PGs) in prostate cancer progression.
- To explore the involvement of PGs in therapy resistance within the prostate cancer context.
- To highlight the differential impact of specific PGs on tumor behavior.
Main Methods:
- This study is a narrative review of existing literature.
- It synthesizes findings on proteoglycans in prostate cancer progression.
- The review focuses on the functional roles of specific PGs.
Main Results:
- Versican, perlecan, and biglycan generally promote prostate cancer progression.
- Decorin and betaglycan exhibit tumor-suppressive roles in prostate cancer.
- Syndecan 1's role in prostate cancer is context-dependent, showing variable effects.
Conclusions:
- Proteoglycans play significant and varied roles in prostate cancer progression and therapy resistance.
- Understanding specific PGs' functions is critical for targeted therapeutic strategies.
- The complex interactions of PGs within the TME warrant further investigation.
Keywords:
biomarkercancer progressionextracellular matrixprostate cancerproteoglycantherapy resistancetumor microenvironmentMore Related Videos
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