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Correlation of Clinical and Laboratory Features of Multisystem Inflammatory Syndrome in Children with

Nenad Barišić1,2, Gordana Vijatov-Đurić1,2, Borko Milanović1,2

  • 1Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.

Medicina (Kaunas, Lithuania)
|December 31, 2025
PubMed

Insights

In children with Multisystem Inflammatory Syndrome, high fever and blood urea nitrogen levels predict abnormal echocardiograms. High-sensitivity troponin I did not show significant predictive value for cardiac findings in MIS-C patients.

Area of Science:

  • Pediatric Cardiology
  • Pediatric Infectious Diseases
  • Pediatric Critical Care Medicine

Background:

  • Multisystem Inflammatory Syndrome (MIS-C) is a serious condition affecting children.
  • Echocardiography is crucial for assessing cardiac involvement in MIS-C.
  • Identifying predictors of echocardiographic abnormalities is vital for timely intervention.

Purpose of the Study:

  • To determine clinical and laboratory markers predicting abnormal echocardiographic findings in pediatric MIS-C.
  • To evaluate the correlation of high-sensitivity troponin I with echocardiographic outcomes.
  • To assess the predictive value of blood urea nitrogen and fever severity.

Main Methods:

  • Retrospective analysis of 61 children (0-18 years) diagnosed with MIS-C.
  • Comparison of clinical and laboratory data between normal and abnormal echocardiography groups.
  • Statistical analysis including point-biserial correlation and logistic regression.

Main Results:

  • Elevated high-sensitivity troponin I was found in 65.57% of MIS-C patients, but did not significantly correlate with echocardiographic findings.
  • Blood urea nitrogen levels and high fever showed a statistically significant positive correlation with abnormal echocardiographic findings.
  • Logistic regression identified blood urea nitrogen and fever as significant predictors (p=0.002 and p=0.013, respectively).

Conclusions:

  • Blood urea nitrogen levels and high fever are significant predictors of abnormal echocardiographic findings in pediatric MIS-C.
  • High-sensitivity troponin I levels are not reliable predictors of cardiac abnormalities in MIS-C.
  • These findings aid in risk stratification and management of children with MIS-C.

Keywords:
blood urea nitrogenechocardiographyfeverhigh sensitive troponin Imultisystem inflammatory syndrome in children (MIS-C)

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