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Lymphocyte Subtypes in Local Inflammatory Response: A Comparative Analysis of Simple and Complicated Appendicitis
Maja Zecevic1,2, Dragoljub Zivanovic1,2, Nikola Zivkovic3
1Clinic for Pediatric Surgery, Orthopedics and Traumatology, University Clinical Center Nis, 18000 Nis, Serbia.
Medicina (Kaunas, Lithuania)
|December 31, 2025
Summary
The appendix
Area of Science:
- Immunology
- Gastroenterology
- Pathology
Background:
- The appendix's immunological role within gut-associated lymphoid tissue is not fully understood.
- Its contribution to intestinal immune system development and maintenance requires further investigation.
Purpose of the Study:
- To analyze appendiceal lymphocyte populations and peripheral blood inflammatory markers.
- To elucidate the immunological function of the appendix in appendicitis.
Main Methods:
- Histopathological examination of 100 appendiceal specimens.
- Immunohistochemical analysis of CD8 T-lymphocytes and CD19 B-lymphocytes.
- Correlation of appendiceal findings with peripheral blood hematological and biochemical parameters.
Main Results:
- CD19 B-lymphocytes were significantly increased in complicated appendicitis.
- CD8 T-lymphocytes were elevated in simple appendicitis but reduced in complicated cases.
- A higher presence of CD19 lymphocytes and a lower count of CD8 lymphocytes were observed in complicated appendicitis.
Conclusions:
- CD8 T-lymphocyte counts are higher in simple appendicitis and lower in complicated appendicitis.
- Increased CD19 B-lymphocytes are associated with complicated appendicitis.
- Appendiceal lymphocyte profiles may indicate disease severity and predict postoperative complications.
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