Early-Life Nutritional Determinants of Pediatric MASLD
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View abstract on PubMed
Summary
This summary is machine-generated.Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) has unique origins, starting in utero. Early life nutrition and maternal health significantly impact offspring liver fat, highlighting critical intervention windows.
Area Of Science
- Hepatology and Metabolic Disorders
- Pediatric Gastroenterology
- Developmental Nutrition
Background
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a widespread liver condition affecting both children and adults.
- Pediatric MASLD presents distinct features compared to adult forms, suggesting unique developmental pathways.
- Intrauterine and early-life factors are increasingly recognized as crucial in the pathogenesis of pediatric MASLD.
Purpose Of The Study
- To review and synthesize evidence on prenatal, postnatal, and early childhood nutritional exposures linked to pediatric MASLD.
- To emphasize the critical early-life windows for potential interventions against pediatric MASLD.
- To understand the multi-hit continuum contributing to MASLD development from in utero.
Main Methods
- Narrative review of existing human cohort studies and mechanistic model systems.
- Synthesis of converging evidence on nutritional exposures and hepatic lipid accumulation.
- Focus on prenatal (maternal health, diet), postnatal (feeding practices), and early childhood (diet quality) factors.
Main Results
- Maternal factors like obesity and gestational diabetes are associated with increased offspring hepatic steatosis.
- Postnatal feeding (breastfeeding vs. formula with added sugars) and early childhood diets influence MASLD susceptibility.
- Combined genetic and environmental factors contribute to the heterogeneity of pediatric MASLD.
Conclusions
- Pediatric MASLD development is a complex continuum influenced by early-life exposures.
- Nutritional interventions during pregnancy and early childhood are vital for preventing MASLD.
- Targeting early-life windows offers a promising strategy to reduce the global burden of pediatric MASLD.
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