Hollow Conductive Polymer Nanospheres with Metal-Polyphenol Interfaces for Tunable Hydrogen Peroxide Activation and...

Hydrogen peroxide (H₂O₂) is a key oxidant for green chemical processes, yet its catalytic utilization and activation efficiency remain limited by material instability and uncontrolled radical release. Here, we report a dual-functional, hollow conductive polymer nanostructure that enables selective modulation of H₂O₂ reactivity through interfacial physicochemical design. Hollow polypyrrole nanospheres functionalized with carboxyl groups (PPy@PyCOOH) were synthesized via a one-step Fe²⁺/H₂O₂ oxidative copolymerization route, in which H₂O₂ simultaneously served as oxidant, template, and reactant. The resulting structure exhibits enhanced hydrophilicity, rapid redox degradability (>80% optical loss in 60 min (82.5 ± 4.1%, 95% CI: 82.5 ± 10.2%), 10 mM H₂O₂, pH 6.5), and strong electronic coupling to reactive oxygen intermediates. Subsequent tannic acid-copper (TA-Cu) coordination produced a conformal metal-polyphenol network that introduces a controllable Fenton-like catalytic interface, achieving a 50% increase in ROS yield (1.52 ± 0.08-fold vs. control, 95% CI: 1.52 ± 0.20-fold) while maintaining stable photothermal conversion under repeated NIR cycles. Mechanistic analysis reveals that interfacial TA-Cu complexes regulate charge delocalization and proton-electron transfer at the polymer-solution boundary, balancing redox catalysis with energy dissipation. This work establishes a sustainable platform for H₂O₂-driven redox and photo-thermal coupling, integrating conductive polymer chemistry with eco-friendly catalytic pathways.