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Microvesicles from Turmeric Extracts Contain Curcuminoids and Modulate Macrophage Polarization and Migration.

Stefano Tacconi1, Audrey Jalabert1, Emmanuelle Berger2

  • 1CarMeN Laboratory (UMR INSERM 1060, INRA 1397), HCL-Lyon Sud, Lyon 1 University, 69152 Pierre-Bénite, France.

Pharmaceutics
|December 31, 2025
PubMed
Summary
This summary is machine-generated.

Turmeric microvesicles (CuMVs) are present in extracts and deliver curcuminoids. Preserving these CuMVs is crucial for turmeric

Keywords:
curcuminimmune responsemacrophagesmicrovesiclesturmeric

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Area of Science:

  • Plant biology
  • Nanotechnology
  • Immunology

Background:

  • Plants produce lipid-derived microvesicles with anti-inflammatory properties.
  • Turmeric (Curcuma longa L.) microvesicles (CuMVs) have shown benefits in colitis models.
  • Phytotherapy extracts may contain CuMVs, influencing their properties.

Purpose of the Study:

  • Investigate CuMV presence in common turmeric extracts.
  • Evaluate extraction process impact on CuMV aggregation and morphology.
  • Assess CuMV immunomodulatory functions.

Main Methods:

  • Standardized extraction and purification (centrifugation, filtration, ultracentrifugation).
  • CuMV characterization (size, aggregation, morphology).
  • Immunomodulatory assays on macrophages (THP-1, RAW).

Main Results:

  • CuMVs (50-200 nm) detected in all extracts; dehydration caused aggregation.
  • Ethanolic extract yielded polydisperse CuMVs containing curcuminoids (curcumin, DMC, BDMC).
  • CuMV treatment modulated macrophage responses (reduced ROS, altered CD86/CD163, increased IL-10, TGF-β, IL-1β, IL-6, TNF-α) and enhanced migration.

Conclusions:

  • CuMVs are key mediators of turmeric extract's immunomodulatory effects.
  • Extraction methods impact CuMV integrity and function.
  • Preserving CuMVs in industrial processing is vital for therapeutic efficacy.