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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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Improved Dissolution of Poorly Water-Soluble Rutin via Solid Dispersion Prepared Using a Fluid-Bed Coating System.

Hien V Nguyen1, Nga Thi-Thuy Nguyen1, Huong Kim-Thien Tran1

  • 1Faculty of Pharmacy, Van Lang University, Ho Chi Minh City 70000, Vietnam.

Pharmaceutics
|December 31, 2025
PubMed
Summary

This study improved rutin

Keywords:
dissolution enhancementfluid-bed coatingrutinsolid dispersionstability

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Area of Science:

  • Pharmacology
  • Materials Science

Background:

  • Rutin, a potent antioxidant and anti-inflammatory agent, has limited use due to poor solubility and bioavailability.
  • Developing effective delivery systems is crucial for rutin's therapeutic potential.

Purpose of the Study:

  • To enhance rutin's dissolution and bioavailability using solid dispersions (SDs) prepared via fluid-bed coating.
  • To formulate these SDs into stable and effective tablet dosage forms.

Main Methods:

  • Rutin was spray-coated onto various carriers using a fluid-bed system.
  • Lactose monohydrate was identified as the optimal carrier, with a 1:10 rutin-to-lactose ratio.
  • Solid dispersions were characterized using PXRD, DSC, SEM, and FT-IR, and formulated into tablets.

Main Results:

  • Lactose monohydrate significantly enhanced rutin dissolution, achieving complete release in 15 minutes.
  • Characterization confirmed reduced crystallinity and improved adsorption of rutin onto lactose monohydrate.
  • Optimized tablets showed enhanced dissolution and stability over 6 months.

Conclusions:

  • Fluid-bed coating is an effective method for creating rutin solid dispersions.
  • This approach can improve the dissolution of rutin and potentially other natural polyphenols.