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Updated: Jan 7, 2026
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Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
Published on: December 14, 2015
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A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies.
Roxana-Georgiana Tauser1, Ioana-Mirela Vasincu1, Andreea-Teodora Iacob1
1Department of Pharmaceutical and Therapeutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania.
Pharmaceutics
|December 31, 2025
Summary
Genomics and epigenomics offer new skin rejuvenation strategies targeting aging hallmarks. This review explores novel approaches like senolytics and epigenetic reprogramming, comparing them to traditional methods for personalized anti-aging therapies.
Area of Science:
- Integrative dermatology and molecular biology.
- Focus on the application of genomics and epigenomics in skin aging research.
Background:
- Skin aging is a complex process influenced by genetic and epigenetic factors.
- Current anti-aging strategies have limitations, necessitating novel approaches.
- Understanding molecular hallmarks of aging is crucial for effective rejuvenation.
Purpose of the Study:
- To review novel genomic and epigenomic strategies for skin rejuvenation.
- To compare these new approaches with traditional anti-aging treatments.
- To highlight knowledge gaps and future research directions in personalized skin aging therapies.
Main Methods:
- Comprehensive literature review of preclinical and clinical studies.
- Analysis of biomarkers, clocks, and therapeutic targets in skin aging.
- Comparative assessment of genomic/epigenomic strategies versus classical treatments.
Main Results:
- Genomic and epigenomic approaches offer new avenues targeting cellular senescence, DNA instability, and epigenetic alterations.
- Novel strategies include senolytics, epigenetic reprogramming, stem cell therapies, and modulation of specific molecular pathways.
- Comparison reveals potential advantages of newer methods in efficacy and mechanism over traditional treatments.
Conclusions:
- Genomics and epigenomics provide a powerful toolkit for advancing skin rejuvenation.
- Personalized anti-aging strategies integrating individual genetic profiles are the future.
- Further research is needed to accelerate the clinical translation of these advanced therapies.
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