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Cell-Mediated and Peptide-Based Delivery Systems: Emerging Frontiers in Targeted Therapeutics.

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Cell-mediated and peptide-assisted delivery systems use cells and peptides to transport therapeutics across biological barriers like the blood-brain barrier (BBB). These advanced platforms show promise for targeted drug delivery in neuro-oncology and immunotherapy.

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Area of Science:

  • Nanotechnology
  • Molecular Medicine
  • Biochemistry

Background:

  • Cell-mediated and peptide-assisted delivery systems leverage cellular and peptide capabilities for therapeutic transport.
  • These platforms overcome biological barriers, including the blood-brain barrier (BBB) and tumor microenvironment.
  • They are crucial for targeted delivery of therapeutic agents.

Purpose of the Study:

  • To review recent advancements in engineered cell carriers, peptide vectors, and hybrid nanostructures.
  • To focus on intracellular and tissue-specific delivery strategies.
  • To highlight applications in neuro-oncology, immunotherapy, and regenerative medicine.

Main Methods:

  • Literature survey of molecular design, mechanistic studies, and in vitro/in vivo evaluations.
  • Emphasis on uptake pathways, endosomal escape, and structure-function relationships.
  • Analysis of cell-mediated and peptide-enabled delivery platforms.

Main Results:

  • Significant progress in optimizing cell-based systems, peptide conjugates, and nanostructures for targeted delivery.
  • Key innovations include enhanced BBB penetration and tumor homing.
  • Efficient cytosolic delivery achieved through advanced peptide designs and engineered cells.

Conclusions:

  • Cell-mediated and peptide-assisted delivery are rapidly evolving fields with broad therapeutic relevance.
  • Challenges in scalability, manufacturing, safety, and regulation persist.
  • Integration of chemical design, molecular engineering, and translational research is vital for clinical impact.