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Advancing Real-Time Polyp Detection in Colonoscopy Imaging: An Anchor-Free Deep Learning Framework with Adaptive
Wanyu Qiu1, Xiao Yang2, Zirui Liu2
1Hubei Key Laboratory of Digital Finance Innovation, Hubei Internet Finance Information Engineering Technology Research Center, School of Information Engineering, Hubei University of Economics, Wuhan 430205, China.
Sensors (Basel, Switzerland)
|December 31, 2025
Summary
This study presents an advanced, anchor-free deep learning model for real-time polyp detection during colonoscopies. The new method significantly improves accuracy and speed, aiding in early colorectal cancer prevention.
Area of Science:
- Medical Imaging
- Computer Vision
- Artificial Intelligence
Background:
- Accurate polyp detection in colonoscopies is crucial for early colorectal cancer (CRC) prevention.
- Existing methods struggle with multi-scale polyp features, inefficient feature fusion, and reliance on complex, less generalizable anchor priors.
Purpose of the Study:
- To develop a real-time, accurate, and generalizable one-stage anchor-free detector for colonoscopic polyp detection.
- To overcome limitations in extracting multi-scale contextual cues and fusing multi-level features.
Main Methods:
- Introduced a Cross-Stage Pyramid Pooling module for efficient multi-scale context aggregation.
- Developed a Weighted Bidirectional Feature Pyramid Network for robust feature fusion.
- Implemented an anchor-free detection head with Scale-invariant Distance with Aspect-ratio IoU loss for direct point-to-boundary regression.
Main Results:
- Achieved state-of-the-art performance with 98.8% mAP@0.5 and 82.5% mAP@0.5:0.95.
- Real-time detection at 35.8 FPS on a GTX 1080-Ti GPU.
- Outperformed leading CNN and Transformer-based models on a large dataset of 103,469 colonoscopy frames.
Conclusions:
- The proposed anchor-free detector offers superior accuracy and efficiency for colonoscopic polyp detection.
- Demonstrates significant potential for clinical application in early CRC screening and prevention.

