Antibacterial Activity and Chemical Analyses of the Alkaloidal Fraction of Neltuma laevigata (Humb. & Bonpl. Ex Willd) Britton & Rose Inflorescences
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.The alkaloidal fraction from Neltuma laevigata inflorescences exhibits significant antibacterial properties against Staphylococcus aureus and Vibrio cholerae. This study also identified Julifloridine, a piperidine alkaloid, for the first time in this species.
Area Of Science
- Phytochemistry
- Pharmacology
- Microbiology
Background
- Neltuma (Prosopis) species are utilized in traditional medicine across continents.
- Neltuma laevigata from Mexico is traditionally used for infections, with activities linked to alkaloids and phenylpropanoids.
Purpose Of The Study
- To evaluate the antibacterial activity of the alkaloidal fraction from Neltuma laevigata inflorescences.
- To investigate the effect of this fraction on bacterial plasmatic membranes.
- To identify specific compounds within the alkaloidal fraction.
Main Methods
- Antibacterial activity assessed using Kirby-Bauer and broth microdilution assays against Staphylococcus aureus and Vibrio cholerae.
- Plasmatic membrane effects studied via protein leakage assays and fluorescence microscopy.
- Compound identification through chromatographic separation, nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HRESIMS).
Main Results
- The alkaloidal fraction demonstrated significant antibacterial activity against both tested bacterial strains.
- Evidence suggests the alkaloidal fraction impacts the cytoplasmic membrane of bacteria.
- Julifloridine, a piperidine alkaloid, was identified in Neltuma laevigata for the first time.
Conclusions
- Neltuma laevigata inflorescences possess potent antibacterial compounds, primarily alkaloids.
- The observed antibacterial effect may involve disruption of the bacterial cytoplasmic membrane.
- The identification of Julifloridine expands the known phytochemical profile of this species.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
