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Antibacterial Agent-Loaded, Novel In Situ Forming Implants Made with Poly(Isosorbide Sebacate) and Dimethyl
Monika Śmiga-Matuszowicz1, Bożena Nowak2, Danuta Wojcieszyńska2
1Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland.
Molecules (Basel, Switzerland)
|December 31, 2025
Summary
Novel biodegradable polymers offer a sustainable alternative for drug delivery. Eugenol addition to these isosorbide-based implants reduced antibiotic release and inflammation, enhancing antibacterial efficacy.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Isosorbide-based aliphatic polyesters offer a sustainable alternative to traditional polymers like poly(α-hydroxy acids) for biomedical uses.
- These bio-based polymers possess inherent structural rigidity, adjustable hydrophilicity, and excellent biocompatibility.
- They are suitable for advanced applications such as targeted drug delivery and eco-friendly medical devices.
Purpose of the Study:
- To develop and characterize novel in situ forming implant (ISFI) formulations using poly(isosorbide sebacate) (PISEB) and dimethyl isosorbide (DMI).
- To evaluate the efficacy of these ISFI formulations for the local delivery of doxycycline hyclate (DOXY), minocycline hydrochloride (MIN), and eugenol (EUG).
- To assess the impact of eugenol on antibiotic release kinetics, depot characteristics, and inflammatory responses.
Main Methods:
- Synthesis and characterization of PISEB-based ISFI formulations.
- Rheological analysis to determine formulation behavior under shear stress.
- In vitro drug release studies for DOXY, MIN, and EUG from the ISFI systems.
- Assessment of eugenol's effect on antibiotic release profiles and inflammatory markers.
Main Results:
- The developed ISFI formulations exhibited advantageous shear-thinning properties.
- MIN-loaded formulations showed rapid drug release (86.4%), while DOXY-loaded formulations had a lower burst release (41.1%).
- Eugenol addition significantly reduced antibiotic release rates, prolonged antibacterial activity, and decreased pro-inflammatory effects by over tenfold.
Conclusions:
- PISEB-based ISFI formulations are promising for local drug delivery applications.
- Eugenol acts as an effective modulator, improving antibiotic release profiles and mitigating inflammatory responses.
- These findings highlight the potential of isosorbide-based polymers for advanced, sustainable biomedical solutions.
