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Related Concept Videos

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...

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Reductive Synthesis of Stable, Polysaccharide in Situ-Modified Gold Nanoparticles Using Disulfide Cross-Linked

Lyudmila V Parfenova1, Eliza I Alibaeva1, Guzel U Gil'fanova1

  • 1Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, Prospekt Oktyabrya, 141, 450075 Ufa, Russia.

Molecules (Basel, Switzerland)
|December 31, 2025
PubMed
Summary

Stable gold nanoparticles were rapidly synthesized using a novel disulfide-crosslinked alginic acid derivative. This green chemistry approach offers a sustainable method for creating hybrid nanoparticles for biomedical and catalytic applications.

Keywords:
Au nanoparticlesalginic acidin situ modified with alginatesize stability

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Green Chemistry

Background:

  • Gold nanoparticles (AuNPs) show promise for biomedical applications.
  • Traditional AuNP synthesis often uses toxic reagents, necessitating eco-friendly alternatives.
  • Biopolymer-based synthesis offers a sustainable route for AuNP production.

Purpose of the Study:

  • To develop a novel, rapid, and green synthesis method for stable gold nanoparticles.
  • To utilize a disulfide-crosslinked alginic acid derivative as both a reducing and stabilizing agent.
  • To characterize the synthesized nanoparticles and assess their stability and potential applications.

Main Methods:

  • Synthesis of disulfide-crosslinked alginic acid (AA-S-S-AA).
  • Reaction of AA-S-S-AA with HAuCl4 in water at room temperature for 10 minutes.
  • Characterization using UV-Vis spectroscopy, electron microscopy, XPS, NMR, and zeta potential measurements.

Main Results:

  • Stable polysaccharide-modified gold nanoparticles (AA-AuNPs) were synthesized rapidly (10 min).
  • Characterization revealed spherical nanoparticles with a bimodal size distribution and a polysaccharide shell, indicating good colloidal stability over 14 days.
  • High negative zeta-potential (-53.9 mV) confirmed strong electrostatic stabilization by the alginate corona.

Conclusions:

  • Sulfur-modified alginic acid is an efficient platform for rapid synthesis of stable, hybrid gold nanoparticles.
  • The green synthesis method avoids toxic reagents, offering a sustainable alternative.
  • The resulting AA-AuNPs are suitable for potential applications in catalysis and biomedicine.