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Mesenchymal Stromal/Stem Cells (MSCs) in Cancer Therapy: Advanced Therapeutic Strategies Towards Future Clinical

Hanna Kucharczyk1, Maciej Tarnowski1, Marta Tkacz1

  • 1Department of Physiology in Health Sciences, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Zolnierska 48, 70-210 Szczecin, Poland.

Molecules (Basel, Switzerland)
|December 31, 2025
PubMed

Insights

Mesenchymal stromal/stem cells (MSCs) show promise for cancer therapy. Researchers are exploring genetic modifications and targeted delivery of therapeutic molecules to enhance their anticancer potential.

Area of Science:

  • Biomedical Engineering
  • Oncology
  • Cell Therapy

Background:

  • Mesenchymal stromal/stem cells (MSCs) are increasingly studied for therapeutic applications.
  • Their potential in developing novel anticancer therapies is a significant research focus.
  • Combining MSC-based strategies with existing clinical treatments is under investigation.

Purpose of the Study:

  • To provide an overview of MSC-based therapeutic strategies for cancer treatment.
  • To assess the potential of engineering MSCs for targeted anticancer effects.
  • To highlight innovative biotechnological approaches utilizing MSCs.

Main Methods:

  • Review of current literature on MSC-based cancer therapies.
  • Focus on genetic modifications of MSCs to express therapeutic molecules (proteins, miRNA, siRNA, lncRNA, circRNA).
  • Examination of strategies involving therapeutic gene delivery and oncolytic viruses.

Main Results:

  • MSC-based strategies offer targeted and therapeutically effective approaches to cancer treatment.
  • Genetic engineering enables MSCs to deliver specific anticancer agents.
  • Delivery of therapeutic genes and oncolytic viruses using MSCs shows potential.

Conclusions:

  • MSCs hold significant promise for innovative cancer therapies.
  • Further research is needed to overcome challenges, including MSCs' bidirectional role.
  • Clinical application requires addressing existing impediments for effective cancer treatment.
Keywords:
MSCsMSCs bidirectional rolecancercancer therapydrug carriersgenetic modifications

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