Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

228
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
228
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

911
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
911
Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

511
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
511
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

736
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
736
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

391
In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
391

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Moisturizing and repairing effects and mechanism of pullulans with different molecular weights on hair.

International journal of biological macromolecules·2026
Same author

A personalized genomic medicine approach to rare genomic disorders associated with simple chromosomal structural variants.

HGG advances·2026
Same author

Corrigendum to "Dual-target carboxymethylated mannan nanoparticles for enhanced pH-responsive monomethyl auristatin E delivery in hepatocellular carcinoma therapy" [Int. J. Biol. Macromol. Volume 339, Part 1, (2026) 149879].

International journal of biological macromolecules·2026
Same author

Use of Machine Learning Techniques for Fertilization Traceability Discrimination via Core Quality Indicators of Korla Fragrant Pear Fruits.

Foods (Basel, Switzerland)·2026
Same author

Rapid Expansion of the Eastern China Lineage (Haplotype P) of <i>Phragmites australis</i> in Caohai Lake, Guizhou, China.

Ecology and evolution·2026
Same author

A dataset on morphology and composition of saltation-sandblasting dust particles from major Chinese source regions.

Scientific data·2026

Related Experiment Video

Updated: Jan 7, 2026

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
07:57

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

Published on: June 24, 2025

988

Current Scientific Advances in Vaccines Against UTIs: Challenges and Prospects.

Baoying Wang1,2,3,4, Yuhui Wang1,2,3,4, Haodi Liu1,2,3,4

  • 1National Glycoengineering Research Center, Shandong University, Qingdao 266237, China.

Microorganisms
|December 31, 2025
PubMed
Summary

Urinary Tract Infection (UTI) vaccines, especially polysaccharide conjugate vaccines, are crucial due to rising antibiotic resistance. This review explores vaccine preparation methods, focusing on optimizing biosynthetic approaches for effective UTI prevention.

Keywords:
antibiotic resistancebiosynthesispolysaccharide conjugate vaccinesurinary tract infectionuropathogenic Escherichia coli

More Related Videos

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis
07:34

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Published on: April 16, 2019

8.6K
Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
10:23

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Published on: December 1, 2017

17.9K

Related Experiment Videos

Last Updated: Jan 7, 2026

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
07:57

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

Published on: June 24, 2025

988
Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis
07:34

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Published on: April 16, 2019

8.6K
Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
10:23

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Published on: December 1, 2017

17.9K

Area of Science:

  • Microbiology
  • Immunology
  • Vaccinology

Background:

  • Urinary Tract Infections (UTIs) are a global health concern, frequently caused by Uropathogenic Escherichia coli (UPEC).
  • Antibiotic resistance in UPEC is escalating, diminishing treatment effectiveness and increasing complication risks.
  • Alternative strategies, particularly vaccines, are urgently needed to combat UTIs.

Purpose of the Study:

  • To review current research on UTI vaccines.
  • To focus on the preparation of polysaccharide conjugate vaccines for UTIs.
  • To analyze traditional chemical and emerging biosynthetic methods for vaccine development.

Main Methods:

  • Review of existing literature on UTI vaccine research.
  • Analysis of polysaccharide conjugate vaccine preparation techniques.
  • In-depth examination of biosynthetic methods for vaccine optimization.

Main Results:

  • Polysaccharide conjugate vaccines are a successful strategy for bacterial infectious diseases.
  • Both chemical conjugation and biosynthetic methods are viable for UTI vaccine preparation.
  • Biosynthetic methods offer potential for optimized UTI vaccine development.

Conclusions:

  • Development of effective UTI vaccines is critical due to antimicrobial resistance.
  • Polysaccharide conjugate vaccines show promise for UTI prevention.
  • Further optimization of biosynthetic methods is key for advancing UTI vaccine development.