Bilateral Cranial Cruciate Ligament Rupture Treatment in a Dog Affected by Classical Ehlers-Danlos Syndrome
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View abstract on PubMed
Summary
This summary is machine-generated.Ehlers-Danlos syndrome (EDS) in dogs can cause joint instability. This case report details a Maltese dog with EDS and bilateral cruciate ligament rupture, highlighting a new genetic variant and surgical stabilization.
Area Of Science
- Veterinary Medicine
- Genetics
- Orthopedics
Background
- Ehlers-Danlos syndrome (EDS) is a congenital connective tissue disorder.
- In humans, EDS is linked to joint instability and increased risk of cranial cruciate rupture.
- Cranial cruciate rupture has not been previously documented in dogs with EDS.
Purpose Of The Study
- To report a case of bilateral cruciate ligament rupture in a dog with Ehlers-Danlos syndrome.
- To identify a potential genetic cause for EDS in the affected canine.
Main Methods
- Clinical examination and diagnosis of bilateral cruciate ligament rupture.
- Genetic analysis to identify variants in collagen genes.
- Surgical stifle stabilization procedure.
Main Results
- An 11-month-old Maltese dog was diagnosed with classical EDS and bilateral cruciate ligament rupture.
- A novel heterozygous COL5A1 missense variant was identified in the affected dog.
- The dog underwent successful stifle stabilization.
Conclusions
- This is the first reported case of cranial cruciate rupture in a dog with EDS.
- A previously undescribed COL5A1 variant may be associated with EDS and cruciate ligament rupture in dogs.
- Surgical stabilization is a viable treatment option for canine EDS patients with cruciate ligament rupture.
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