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Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

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Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
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Heart Failure I: Introduction01:27

Heart Failure I: Introduction

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

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The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
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Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Updated: Jan 7, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
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Increased Heart Failure Risk with Gastric Cancer Progression: A Nationwide Population-Based Cohort Study.

Seunghan Lee1, Mi Jin Oh1, Bokyung Kim1

  • 1Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Gut and Liver
|December 31, 2025
PubMed
Summary

The risk of heart failure increases with gastric cancer stage. Patients with distant-stage gastric cancer have a nearly threefold higher risk of heart failure requiring hospitalization compared to those with localized disease.

Keywords:
EpidemiologyGastric cancerHeart failureRisk factorsSEER Program

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Area of Science:

  • Oncology
  • Cardiology
  • Public Health

Background:

  • Gastric cancer survival rates are improving due to treatment advances.
  • There is a growing interest in non-cancer-related conditions, especially cardiovascular diseases, in gastric cancer survivors.
  • The relationship between gastric cancer stage and heart failure risk requires further investigation.

Purpose of the Study:

  • To investigate the risk of heart failure in patients with gastric cancer.
  • To analyze heart failure risk based on the initial stage of gastric cancer.

Main Methods:

  • A nationwide, population-based, retrospective cohort study was conducted using the Korean Cancer Public Library Database.
  • Patients diagnosed with gastric cancer between 2012 and 2019 were followed until 2020.
  • Gastric cancer staging (localized, regional, distant) was based on the Surveillance, Epidemiology, and End Results Program criteria.

Main Results:

  • A total of 202,347 gastric cancer patients were included; 7.9% developed heart failure.
  • Heart failure incidence significantly increased with advanced gastric cancer stages (p<0.001).
  • Adjusted hazard ratios for heart failure were 1.52 (regional stage) and 2.87 (distant stage) compared to the localized stage.

Conclusions:

  • The risk of heart failure requiring hospitalization escalates with worsening gastric cancer stage.
  • Close heart failure monitoring is crucial for all gastric cancer patients, including younger individuals and those without metabolic risk factors.
  • These findings highlight the importance of integrated care for gastric cancer patients, addressing both oncological and cardiovascular health.