Effects of Autologous Blood-Derived Extracellular Vesicles on Skin Regeneration and Anti-Aging: A Clinical Study

Autologous blood-derived extracellular vesicles (EVs) have gained attention as a novel therapeutic approach for skin rejuvenation. This study evaluates their efficacy in improving wrinkles, lifting, hydration, barrier function, tone, radiance, texture, and pore size in human subjects.

This study aimed to evaluate the clinical efficacy of a single intradermal injection of autologous blood-derived EVs in improving multiple skin parameters, including wrinkle reduction, skin lifting, hydration, barrier function, tone, radiance, texture, and pore size, over a three-week period.

Twenty-five participants aged 40-59 underwent a single facial injection of autologous blood-derived EVs. Evaluations were conducted before treatment, 5 days post-treatment, and 3 weeks post-treatment using objective skin analysis tools and subjective self-assessment questionnaires.

Statistically significant improvements (p < 0.05) were observed in wrinkle depth, skin lifting, hydration, elasticity, and barrier function at both 5-day and 3-week time points. Skin tone, radiance, texture, and pore size also improved significantly over the study period. Subjective self-assessments corroborated the instrumental findings, with a marked increase in participant-reported satisfaction. No adverse reactions or safety concerns were reported during the study.

This study demonstrates the clinical efficacy and safety of autologous blood-derived EVs in facial rejuvenation, supporting their potential as a non-invasive cosmetic treatment.