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Association between ABCG2 polymorphisms and allopurinol response in gout patients: a systematic review and
Jia Wen Lee1, Muhammad Danish Badrul Hisham1,2, Xin Yee Low1
1Faculty of Pharmacy and Biomedical Sciences, MAHSA University, Jenjarom, Malaysia.
Aim:
This systematic review and meta-analysis aimed to investigate the association between ABCG2 polymorphisms and allopurinol response in gout patients.
Methods:
A comprehensive search of Scopus, PubMed, Web of Science, EBSCOhost, and the Clinical Pharmacogenomic Resource was conducted for observational studies up to May 2025. Two authors independently screened studies, extracted data, and assessed study quality using the Newcastle-Ottawa Scale. Pooled odds ratios with 95% confidence intervals were calculated using a random-effects model across codominant, dominant, and recessive genetic models. Statistical heterogeneity was evaluated using the I2 statistic, and sensitivity analyses were performed.
Results:
Six studies met the inclusion criteria for the review, and five were included in the meta-analysis. A significant association was observed between rs2231142 with poor allopurinol response, but not rs10011796. Sensitivity analyses confirmed the robustness of the findings for rs2231142.
Conclusion:
The findings suggest that ABCG2 rs2231142 influences allopurinol response. These results underscore the potential of rs2231142 as a predictive genetic marker for allopurinol efficacy and may inform the development of pharmacogenomic guidelines for gout management.This systematic review and meta-analysis was not registered in any protocol registry.
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