Related Experiment Video

Updated: Jan 7, 2026

A Flow Cytometry-based Assay for Measuring Mitochondrial Membrane Potential in Cardiac Myocytes After Hypoxia/Reoxygenation
07:14

A Flow Cytometry-based Assay for Measuring Mitochondrial Membrane Potential in Cardiac Myocytes After Hypoxia/Reoxygenation

Published on: July 13, 2018

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RETRACTION: Notch1 Protects Against Myocardial Ischaemia-Reperfusion Injury via Regulating Mitochondrial Fusion and

    Journal of Cellular and Molecular Medicine
    |December 31, 2025
    PubMed

    Insights

    This study on Notch1 and myocardial ischemia-reperfusion injury is retracted due to duplicated figures and unreliable data. The authors voluntarily requested retraction after concerns were raised.

    Area of Science:

    • Cardiovascular Research
    • Molecular Medicine
    • Cellular Biology

    Background:

    • Myocardial ischemia-reperfusion (I/R) injury is a significant clinical challenge.
    • The role of Notch1 signaling in cardiac protection requires further elucidation.

    Purpose of the Study:

    • To investigate the protective effects of Notch1 against myocardial I/R injury.
    • To explore the underlying mechanisms involving mitochondrial dynamics.

    Main Methods:

    • The study utilized experimental models to assess myocardial I/R injury.
    • Mitochondrial fusion and function were evaluated using specific assays.

    Main Results:

    • The original study suggested Notch1 activation conferred protection against myocardial I/R injury.
    • Proposed mechanisms involved the regulation of mitochondrial fusion and improved mitochondrial function.

    Conclusions:

    • The retracted study concluded that Notch1 plays a protective role in myocardial I/R injury.
    • Concerns regarding data integrity, specifically duplicated figures, led to the retraction.
    Abstract

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