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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

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Related Experiment Video

Updated: Jan 7, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Lobe-Less, a Long Noncoding RNA That Regulates Drosophila Mushroom Body Morphogenesis.

Sachi Inagaki¹, Natsuki Nakamura², Mitsutaka Kadota^3,4

¹Biosignal Research Center, Kobe University, Kobe, Japan.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms

|December 31, 2025

Summary

This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are crucial for neural development. This study reveals the Lobe-less (LOL) lncRNA

Keywords:

drosophila Polycomb group genes axon guidance central nervous system long noncoding RNA (lncRNA)mushroom body

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Last Updated: Jan 7, 2026

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Ex vivo Culturing of Whole, Developing Drosophila Brains

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Published on: July 27, 2012

Area of Science:

Neuroscience
Epigenetics
Molecular Biology

Background:

Long noncoding RNAs (lncRNAs) are transcribed in eukaryotes, but their roles in neural development are largely unknown.
In vivo studies on lncRNA functions, particularly in the nervous system, are limited.

Purpose of the Study:

To investigate the physiological role of the Lobe-less (LOL) long noncoding RNA in Drosophila neural development.
To elucidate the molecular mechanisms by which LOL lncRNA regulates neural circuit formation.

Main Methods:

Analysis of lol mutant Drosophila melanogaster.
Examination of mushroom body morphology and axon branching patterns.
Gene expression analysis of neurogenic genes.
Investigation of LOL RNA localization and genetic interactions with Polycomb group genes.

Main Results:

LOL lncRNA is expressed in developing Drosophila neuronal cells.
lol mutant flies display defects in mushroom body morphology and axon patterning.
Misregulation of neurogenic genes was observed in lol mutants.
LOL RNA forms nuclear puncta and interacts with Polycomb group genes to regulate homeotic genes.

Conclusions:

The Lobe-less (LOL) lncRNA is essential for the proper development of the Drosophila mushroom body, a key learning and memory center.
LOL lncRNA plays a critical role in the epigenetic control of neural circuit formation through interactions with Polycomb group genes.