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Frontiers in thoracic oncology: new breakthroughs in molecular targets and immunotherapy

Yujing Yang1, Dan Pu2, Xuehan Li1

  • 1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Immunology
|December 31, 2025
PubMed

Insights

New molecular targeted therapy and immunotherapy strategies show promise for treating thoracic tumors like lung cancer, offering improved outcomes and fewer side effects compared to traditional methods.

Area of Science:

  • Oncology
  • Thoracic Surgery
  • Medical Therapeutics

Background:

  • Thoracic tumors (lung cancer, breast cancer, thymoma) often have poor prognoses.
  • Current treatments for thoracic tumors exhibit limited efficacy and significant adverse effects.
  • Emerging molecular targeted therapy and immunotherapy present novel treatment avenues.

Purpose of the Study:

  • To review the latest advancements in molecular targeted therapy and immunotherapy for thoracic tumors.
  • To discuss the clinical applications, challenges, and potential solutions for these novel therapeutic strategies.
  • To provide a foundation for improving thoracic tumor patient outcomes and guide future research.

Main Methods:

  • Comprehensive literature review of recent studies on targeted therapy and immunotherapy for thoracic malignancies.
  • Analysis of clinical trial data and research findings.
  • Synthesis of information regarding efficacy, safety, and applicability.

Main Results:

  • Molecular targeted therapy and immunotherapy demonstrate potential for improved efficacy in thoracic tumors.
  • These novel approaches may offer reduced toxicity compared to conventional treatments.
  • Identified challenges include resistance mechanisms and optimal patient selection.

Conclusions:

  • Molecular targeted therapy and immunotherapy represent a significant paradigm shift in thoracic tumor treatment.
  • Further research is needed to overcome current challenges and optimize clinical application.
  • These strategies hold promise for enhancing survival and quality of life for patients with thoracic tumors.
Keywords:
immune cell communicationimmunotherapymolecular targeted therapythoracic tumorstreatment progress

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