Cellular Angiofibroma of the Prostate

Cellular angiofibroma is a rare, benign mesenchymal tumor that affects middle-aged adults. It most frequently arises in the vulvovaginal or inguinoscrotal region. It is characterized by a slow clinical progression with no known potential for recurrence or metastasis.

In this case, we report a 78-year-old man presenting with obstructive lower urinary tract symptoms. Transrectal ultrasonography revealed a prostate volume of approximately 150 cc. The patient underwent an open retropubic prostatectomy (Hryntschak) to relieve symptoms. Histopathological evaluation revealed a proliferation of bland, spindle-shaped cells within a collagenous stroma interspersed with dilated, thick-walled blood vessels. Immunohistochemical analysis showed positivity for smooth muscle actin, desmin, and CD34 and negative staining for S100. Fluorescence in situ hybridization revealed a deletion at chromosome 13q14. These morphological and molecular findings support the diagnosis of cellular angiofibroma.

To our knowledge, this is a rare case of cellular angiofibroma originating in the prostate.