Cellular Angiofibroma of the Prostate

Area of Science:

• Oncology
• Urology
• Pathology

Background:

• Cellular angiofibroma is a rare, benign mesenchymal tumor typically affecting middle-aged adults.
• It commonly occurs in the vulvovaginal or inguinoscrotal regions and has no metastatic potential.
• This tumor presents with slow clinical progression.

Purpose of the Study:

• To report a rare case of cellular angiofibroma originating in the prostate.
• To describe the clinical, histopathological, and molecular features of this unusual presentation.

Main Methods:

• A 78-year-old man with obstructive lower urinary tract symptoms underwent open retropubic prostatectomy.
• Histopathological evaluation included routine staining and immunohistochemistry.
• Fluorescence in situ hybridization was performed for molecular analysis.

Main Results:

• The prostate measured approximately 150 cc and showed a proliferation of spindle-shaped cells in a collagenous stroma with vascular proliferation.
• Immunohistochemistry was positive for smooth muscle actin, desmin, and CD34, and negative for S100.
• A deletion at chromosome 13q14 was identified.

Conclusions:

• The findings support the diagnosis of cellular angiofibroma of the prostate.
• This represents a rare occurrence of cellular angiofibroma in this anatomical location.
• Further research may be needed to understand the behavior and management of prostatic cellular angiofibroma.