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Association of SLC14A1C/T Polymorphisms in Patients with Bladder Cancer in Comparison with Healthy Controls
Saziya Bidi1,2, R B Nerli1,2, Shadab Rangrez3
1Urinary Biomarkers Research Centre, KLES Dr. Prabhakar Kore Hospital & Medical Research Centre, Nehru Nagar, Belagavi, Karnataka, India.
South Asian Journal of Cancer
|December 31, 2025
Summary
Gene polymorphisms in the SLC14A1 gene are linked to increased bladder cancer risk. Tobacco use, including smoking and chewing, further elevates this risk in patients with these genetic variations.
Area of Science:
- Urology
- Genetics
- Oncology
Background:
- Bladder cancer is a common malignancy characterized by genomic instability.
- SLC14A1 gene polymorphisms are implicated in bladder cancer development.
- Tobacco use is a known risk factor for bladder cancer.
Purpose of the Study:
- To investigate the association between SLC14A1 gene polymorphisms (rs17674580) and bladder cancer risk.
- To determine if tobacco use exacerbates bladder cancer risk in individuals with SLC14A1 variants.
Main Methods:
- A case-control study involving 107 bladder cancer patients and age/gender-matched controls.
- Genotyping of SLC14A1 C/T polymorphisms (rs17674580) from blood samples.
- Assessment of tobacco use (smoking/chewing) history.
Main Results:
- 73.8% of bladder cancer patients exhibited SLC14A1 gene polymorphisms.
- Odds ratios for heterozygous (CT) and homozygous (CC/TT) variations were 2.772 and 3.349, respectively.
- Tobacco use was found to modulate bladder cancer risk in patients with SLC14A1 variants.
Conclusions:
- SLC14A1 C/T gene polymorphisms are associated with a significantly higher risk of bladder cancer.
- Combined effect of SLC14A1 polymorphisms and tobacco use increases bladder cancer risk.
Keywords:
gene polymorphismshistopathologysouth Indiatobacco (smoking/chewing)transitional cell carcinomaMore Related Videos
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