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Geographic shift of Japanese spotted fever and diagnostic overshadowing by COVID-19 testing: A genetically confirmed

Hiroaki Hara1, Jiro Kamiyama1, Ryoichiro Kondo1

  • 1Saitama Red Cross Hospital Advanced Emergency Medical Center, Saitama City, Japan.

Idcases
|December 31, 2025
PubMed

Insights

Japanese spotted fever (JSF), caused by Rickettsia japonica, is expanding its geographic range. This case highlights the need for broad differential diagnosis beyond COVID-19, especially with conflicting clinical presentations.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Japanese spotted fever (JSF), caused by Rickettsia japonica, is typically found in western and southern Japan.
  • Recent cases indicate an expansion into urban and non-endemic regions.
  • Differentiating JSF from other febrile illnesses, like COVID-19, can be challenging.
Keywords:
COVID-19Japanese spotted feverRickettsial diseaseSepsisTetracycline

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