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Enterovirus 71 seropositivity among children and adolescents in Bangladesh

Sabeena Ahmed1, Mohammad M Karim1, Ching S Phru1

  • 1International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

IJID Regions
|December 31, 2025
PubMed

Insights

Enterovirus 71 (EV71) neutralizing antibody seroprevalence was high in Bangladeshi children, indicating widespread exposure. Risk factors varied between urban and rural settings, highlighting the need for targeted surveillance and prevention strategies.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Non-polio enterovirus infections are a growing global concern.
  • Enterovirus 71 (EV71) is a significant enterovirus with potential for severe neurological disease.

Purpose of the Study:

  • To assess the seroprevalence of EV71 neutralizing antibodies (NAbs) in children and adolescents in Bangladesh.
  • To identify risk factors associated with EV71 infection in different settings.

Main Methods:

  • A cross-sectional survey was conducted from March 2019 to March 2020 in urban and rural Bangladesh.
  • Serum samples from 1207 children aged 0-17 years were tested for EV71 NAbs using microneutralization assays.
  • Demographic and socio-epidemiological data were collected via structured interviews.

Main Results:

  • Overall EV71 seropositivity was 67.7%, with higher rates in urban (68.3%) than rural (31.7%) areas.
  • Seroprevalence varied significantly by age and setting, with very high rates in infants and young children in urban areas.
  • In urban areas, indoor toilet access was linked to lower seropositivity; in rural areas, older age, lower parental education, and unemployment were significant risk factors.

Conclusions:

  • The high seroprevalence of EV71 in Bangladeshi children suggests extensive population exposure.
  • Findings underscore the need for enhanced surveillance and targeted prevention strategies for non-polio enteroviruses, including EV71.
  • Further research is crucial to inform potential vaccine development and public health interventions.
Abstract

Keywords:
BangladeshChildrenEnterovirus 71 (EV71)Hand-foot-and-mouth diseaseNeutralizing antibodySeroprevalence

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