Related Experiment Video
Updated: Jan 7, 2026
Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
Published on: November 30, 2022
Topological Radiomics in Predicting Mucosal Healing and Activity Score of Crohn's Disease Using Multi-Task Deep
Kaiqiang Tang1, Xinyan Wu1,2, Junlin Li3
1Department of Radiology, Chongqing General Hospital, Chongqing University, Chongqing, 401147, People's Republic of China.
Background:
Endoscopic evaluation remains the gold standard for assessing Crohn's disease (CD) activity and mucosal healing (MH), but it is invasive, expensive and time consuming. Therefore, there is an urgent need for a non-invasive quantitative alternative method.
Aim:
To develop a topological radiomics-based multi-task deep learning model for simultaneous prediction of MH status and endoscopic activity scores in CD.
Methods:
A total of 81 CD patients were stratified into training (n=60) and validation (n=21) groups at a 7:3 ratio. Topological radiomic features were extracted from multiphase CT enterography. A multi-task model was trained to predict MH (classification) and SES-CD (regression), integrating feature selection and SHAP-based interpretability.
Results:
Three discriminative topological features were identified across arterial and portal phases. For MH prediction, the multi-task model achieved an AUC of 0.938 for training set and 0.875 for validation set. For SES-CD prediction, it showed lower MSE and MAE, with higher R2 and C-index than the single-phase models.
Conclusion:
The multi-task topological radiomics framework enables accurate, non-invasive assessment of mucosal healing and endoscopic activity in CD, offering a clinically interpretable approach with strong translational potential. Future studies with larger cohorts are warranted to further validate its robustness.
