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Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
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Genetic Polymorphisms and Gene-Environment Interactions in Persistent Post-Stroke Depression.

Yan Lan1, Xianxian Li1, Xin Zhao1

  • 1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Neuropsychiatric Disease and Treatment
|December 31, 2025
PubMed
Summary
This summary is machine-generated.

Persistent post-stroke depression (PSD) is linked to genetic variants. The rs9965081 single nucleotide polymorphism (SNP) interacts with LDL-C levels, increasing susceptibility to persistent PSD in stroke patients.

Keywords:
ischemic stroke cohortlow‑density lipoprotein cholesterolrs9965081whole‑exome sequencing

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Post-stroke depression (PSD) is a common complication after stroke.
  • Persistent PSD has a higher symptom burden and poorer long-term outcomes.
  • Mechanisms underlying persistent PSD are not fully understood.

Purpose of the Study:

  • Investigate genetic variants associated with persistent PSD.
  • Evaluate gene-environment (G×E) interactions with modifiable stroke risk factors.
  • Determine if genotype influences susceptibility across different environmental exposures.

Main Methods:

  • Recruited patients with first-onset acute ischemic stroke.
  • Utilized whole-exome sequencing (WES) for initial SNP screening.
  • Applied G×E interaction models to explore environmental modulation of genetic risk.

Main Results:

  • Identified nine SNPs potentially related to PSD onset via WES.
  • rs9965081 showed significant correlation with persistent PSD.
  • rs9965081 interacts with serum low-density lipoprotein cholesterol (LDL-C) levels.

Conclusions:

  • rs9965081 is a potential persistent PSD-associated SNP.
  • This SNP interacts with serum LDL-C levels in persistent PSD development.
  • Carriers of the rs9965081 risk allele are more susceptible to persistent PSD due to LDL-C fluctuations.