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A comparison of single session and multiple session microwave ablation for multiple lung malignancies
Bohan Song1, Jinfeng Bai1, Hongtao Lei2
1Department of Minimally Invasive Intervention, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, China.
Journal of Cancer Research and Therapeutics
|December 31, 2025
Summary
Single session microwave ablation (MWA) offers superior survival and local tumor control for multiple malignant lung tumors compared to multiple sessions. Complication rates remain similar between single and multiple MWA sessions.
Area of Science:
- Interventional Radiology
- Oncology
- Pulmonology
Background:
- Multiple malignant lung tumors present a therapeutic challenge.
- Microwave ablation (MWA) is an emerging treatment modality for lung malignancies.
Purpose of the Study:
- To compare the therapeutic efficacy and safety of single-session versus multiple-session MWA for multiple malignant lung tumors.
Main Methods:
- Retrospective analysis of 103 patients with multiple malignant lung tumors treated between January 2020 and December 2022.
- Patients were divided into single-session and multiple-session MWA groups.
- Outcomes assessed included overall survival (OS), local progression-free survival (PFS), technical success, and safety.
Main Results:
- Single-session MWA demonstrated significantly superior median OS (33 months) and local PFS (26 months) compared to multiple-session MWA (13.1 months OS, P = 0.001).
- Factors adversely affecting survival included T stage, comorbidity, tumor interior environment, and multiple MWA sessions.
- No treatment-related deaths or severe adverse events occurred; pneumothorax was the most common complication (13.1%), with no significant difference between groups.
Conclusions:
- Single-session MWA is superior to multiple-session MWA for multiple malignant lung tumors regarding survival and local tumor control.
- There is no significant difference in complication rates between single and multiple MWA sessions.
- Single-session MWA may be a more advantageous treatment approach.
