Emergence of antibiotic-resistant pneumococcal serotypes causing invasive pneumococcal disease in children, Spain
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View abstract on PubMed
Summary
This summary is machine-generated.Pneumococcal conjugate vaccines (PCVs) reduced invasive pneumococcal disease (IPD) in children. However, antibiotic-resistant strains, particularly non-PCV13 serotypes like 24F, are increasing, posing a new challenge.
Area Of Science
- Microbiology
- Epidemiology
- Vaccinology
Background
- Pneumococcal conjugate vaccines (PCVs) have decreased invasive pneumococcal disease (IPD) globally.
- The emergence of non-vaccine serotypes with reduced antibiotic susceptibility is a concern.
- Surveillance of antibiotic resistance patterns is crucial for public health.
Purpose Of The Study
- To analyze changes in antibiotic-resistant *Streptococcus pneumoniae* strains causing IPD in children.
- To evaluate the impact of PCV13 and the COVID-19 pandemic on antibiotic resistance.
- To identify prevalent non-vaccine serotypes contributing to IPD-RS.
Main Methods
- National surveillance of 4,455 pediatric IPD isolates in Spain (2009-2023).
- Analysis of antibiotic susceptibility to penicillin and erythromycin.
- Stratification of data into six periods: pre-PCV13, early, middle, late PCV13, COVID-19, and reopening.
Main Results
- Overall IPD cases decreased significantly (over 60% in 1-4 years, 50% in <1 year).
- Increased incidence of IPD-RS caused by non-PCV13 serotypes, with 24F being most prevalent.
- PCV13 introduction substantially reduced IPD; COVID-19 caused a temporary decline in resistant strains.
Conclusions
- PCV13 effectively reduced IPD but led to an increase in non-PCV13 serotype resistance.
- Serotype 24F is a growing concern for antibiotic resistance in IPD.
- Pandemic measures temporarily lowered resistant strain burden, followed by recovery.
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