Related Experiment Video
Updated: Jan 7, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Enantioselective Synthesis of Functionalized 2,2-Disubstituted Piperidines Enabled by Pd-Catalyzed Decarboxylative
Zhenzhen Wang1, Dan Chen1, Junhai Chang1
1Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Abstract:
Herein, we report a palladium-catalyzed decarboxylative asymmetric allylic alkylation (Pd-DAAA) for the synthesis of enantioenriched 2,2-disubstituted piperidines. This method efficiently constructs aza-quaternary stereocenters with high enantioselectivity and broad functional group compatibility. Its utility is demonstrated through access to synthetically useful azacyclic building blocks, a formal synthesis of arbornamine, and the identification of potent antileukemia agents, establishing Pd-DAAA as a robust strategy for chiral piperidine and α-tertiary amine synthesis.
More Related Videos
09:54Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
Published on: September 12, 2018
11:45Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Related Concept Videos
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Cycloaddition Reactions: Overview
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry