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Lower Adherence to Vitamin D Prophylaxis in Families With Multiple Children

Martina Panicola1, Giulia Cereghetti2, Carlo Agostoni1,3

  • 1Department of Clinical Sciences and Community Health, Università Degli Studi di Milano, Milan, Italy.

Acta Paediatrica (Oslo, Norway : 1992)
|December 31, 2025
PubMed

Insights

Infants in families with multiple children showed lower adherence to vitamin D supplementation. This finding highlights the need for targeted support to ensure adequate vitamin D intake for all infants.

Area of Science:

  • Pediatrics
  • Public Health
  • Nutritional Science

Background:

  • Vitamin D supplementation is crucial for infant health.
  • Factors influencing adherence to vitamin D prophylaxis require investigation.

Purpose of the Study:

  • To examine the association between family composition and adherence to vitamin D supplementation in infants.
  • To identify household factors impacting vitamin D prophylaxis adherence.

Main Methods:

  • Cross-sectional survey of 241 caregivers of infants (4-12 months) in Milan, Italy.
  • Data collected on demographics, health, vitamin D administration, and family characteristics.
  • Multivariable logistic regression analyzed factors associated with poor adherence.

Main Results:

  • Overall adherence to vitamin D supplements (≥4 times/week) was 85%.
  • Good adherence was higher in single-child families (91%) vs. multi-child families (78%).
  • Having siblings was significantly associated with poor adherence (OR 2.72, 95% CI 1.25-5.92).

Conclusions:

  • Adherence to vitamin D prophylaxis was significantly lower in families with more than one child.
  • Family size is a key factor influencing vitamin D supplementation adherence in infants.
  • Findings can inform counseling and interventions to improve vitamin D adherence.
Abstract

Keywords:
Sibshipadherencefamily sizericketsvitamin D prophylaxis

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