The Association between Oxidative Balance Score and Sleep Disorders in Allergic Rhinitis Patients: Evidence from...

Oxidative stress is associated with sleep disorders, yet the relationship between OBS - as a comprehensive measure of individual oxidative stress levels - and sleep disorders in allergic rhinitis (AR) patients remains unexplored. This study aimed to investigate whether OBS was associated with sleep disorders in AR patients.

The data presented in this study were obtained from the NHANES 2005-2006 database. Sleep disorder was determined by participants' responses to the question "Ever told by a doctor have a sleep disorder?" in the NHANES questionnaire. Univariate and multivariate logistic regression were used to analyze the association between OBS, dietary OBS, lifestyle OBS, and sleep disorders. The nonlinear relationship was further explored by RCS analysis. Mediating analysis was conducted to investigate potential mediating factors influencing the relationship between OBS/lifestyle OBS and sleep disorders.

The data of 904 patients with AR were included in this study, of which 64 patients had sleep disorders and 840 patients had no sleep disorders. OBS and lifestyle OBS were associated with sleep disorders in AR patients. RCS results revealed that OBS (p for nonlinear = 0.579) and lifestyle OBS (p for nonlinear = 0.876) had a negative and linear relationship with sleep disorders. The results of the mediating analysis showed that direct HDL-C was a mediator in the relationship between OBS and sleep disorders, as well as lifestyle OBS and sleep disorders.

OBS and lifestyle OBS were associated with sleep disorders in AR patients. Besides, direct HDL-C was a mediator in their relationship.