Methodological characteristics of Peruvian clinical practice guidelines, 2018 - 2023: A scoping review

Area of Science:

• Health Services Research
• Clinical Methodology
• Evidence-Based Medicine

Background:

• Clinical practice guidelines (CPGs) require rigorous methodology for reliable recommendations.
• Methodological standards of CPGs in Peru are not well-documented.

Purpose of the Study:

• To assess the methodological characteristics of CPGs published in Peru from 2018 to 2023.

Main Methods:

• A scoping review of CPGs was conducted using online searches.
• Inclusion criteria required self-identification as CPGs, full-text availability, explicit methodology, and systematic review basis.
• Data were analyzed descriptively, with Fisher's exact tests for organizational differences.

Main Results:

• 88 CPGs met criteria, with a declining publication trend.
• EsSalud developed most CPGs (60.2%); oncology was the most common specialty (20.5%).
• Methodological deficiencies included inadequate search reporting (23.7% used ≥3 engines), incomplete bias assessment reporting (76.3%), and missing key GRADE components (e.g., Summary of Findings tables, Evidence-to-Decision frameworks).

Conclusions:

• Peruvian CPGs exhibit substantial methodological deficiencies in reporting search strategies, bias assessments, and critical GRADE elements.
• Improving CPG methodology is essential for enhancing healthcare quality and ensuring equitable delivery in Peru.