Related Experiment Video
Updated: Jan 7, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Al 18 F-NOTA-HER2-BCH Versus 18 F-FDG PET/CT for Detecting Bone Metastases : Sensitivity and Quantitative Comparison.
Xiaoyi Guo1, Jiayue Liu1, Huan Ma1
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine.
Al18F-NOTA-HER2-BCH PET/CT shows superior bone metastasis detection in HER2-positive breast cancer compared to 18F-FDG PET/CT. This novel agent is particularly effective for detecting small and early-stage lesions.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- HER2-positive breast cancer frequently metastasizes to bone.
- Accurate detection of bone metastases is crucial for treatment planning and prognosis.
- 18F-FDG PET/CT is a standard imaging modality, but its sensitivity for bone metastases can be limited.
Purpose of the Study:
- To compare the diagnostic performance of Al18F-NOTA-HER2-BCH PET/CT and 18F-FDG PET/CT.
- To evaluate the detection rates of bone and visceral metastases in HER2-positive breast cancer patients.
Main Methods:
- Retrospective analysis of 64 HER2-positive breast cancer patients.
- Comparison of Al18F-NOTA-HER2-BCH PET/CT and 18F-FDG PET/CT imaging.
- Lesion assessment by two independent readers, quantifying uptake with SUVmax and TBR.
Main Results:
- Al18F-NOTA-HER2-BCH PET/CT demonstrated higher sensitivity (100.0%) and accuracy (96.9%) for bone metastases compared to 18F-FDG PET/CT (87.0% and 93.8%).
- Complete detection of osteoblastic, osteolytic, and CT-occult bone lesions was achieved with Al18F-NOTA-HER2-BCH.
- Al18F-NOTA-HER2-BCH detected significantly more sub-centimeter bone metastases and showed potential for earlier visceral metastasis identification.
Conclusions:
- Al18F-NOTA-HER2-BCH PET/CT offers superior detection of bone metastases in HER2-positive breast cancer.
- This agent is particularly valuable for identifying early-stage, CT-occult, and small bone lesions.
- Al18F-NOTA-HER2-BCH PET/CT may improve the detection of concurrent visceral metastases.
More Related Videos
07:15Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
Published on: August 16, 2020
06:51Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018