Al 18 F-NOTA-HER2-BCH Versus 18 F-FDG PET/CT for Detecting Bone Metastases : Sensitivity and Quantitative Comparison.

Xiaoyi Guo1, Jiayue Liu1, Huan Ma1

  • 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine.

Clinical Nuclear Medicine
|December 31, 2025
PubMed
Summary

Al18F-NOTA-HER2-BCH PET/CT shows superior bone metastasis detection in HER2-positive breast cancer compared to 18F-FDG PET/CT. This novel agent is particularly effective for detecting small and early-stage lesions.