Exploring gut microbiome and nutritional status among children with Autism Spectrum Disorder (MY-ASD Microbiome): A...

Area of Science:

• Microbiology
• Neuroscience
• Pediatrics

Background:

• Autism Spectrum Disorder (ASD) is a neurodevelopmental condition with unclear gut-brain axis mechanisms.
• Gut microbiota dysbiosis is frequently observed in ASD, with potential for microbial biomarkers.
• Children with ASD face increased malnutrition risk due to eating behaviors.

Purpose of the Study:

• To identify oral and gut microbiota profiles in children with ASD compared to typically developing (TD) children.
• To determine associations between oral/gut microbiota and nutritional status in children with ASD.
• To enhance understanding of ASD etiology and inform early intervention strategies.

Main Methods:

• Observational, age-matched case-control study in Malaysia involving 40 male children with ASD and 40 TD controls (ages 4-10).
• Metagenomic sequencing of saliva and fecal samples to analyze microbiota.
• Nutritional status assessed via SGNA, anthropometry, dietary intake; autism severity via validated questionnaires.

Main Results:

• Microbiota profiles in oral and gut samples will be identified.
• Associations between specific microbiota and nutritional status markers will be determined.
• Data collection is ongoing, with analysis planned post-June 2026.

Conclusions:

• This research will advance the understanding of ASD-associated microbiota.
• Findings are expected to guide personalized nutrition approaches for ASD.
• The study aims to contribute to precision healthcare strategies in Malaysia.