Association between Serum Ferritin and Preeclampsia

Preeclampsia (PE) is a common obstetrical disorder. It is a major cause of morbidity and mortality of mother as well as fetus. Its complex pathophysiology still remains unclear. Serum ferritin is an important marker of status of iron. Iron plays role as a catalyzer of oxidative stress as well as lipid peroxidation in the pathophysiology of preeclampsia. This study was conducted with an aim to explore the relation between serum ferritin and preeclampsia. This cross sectional comparative research was carried out in the Department of Obstetrics and Gynecology of Mymensingh Medical College Hospital, Bangladesh from March 2021 to September 2022. A total of 62 singleton pregnant women with preeclampsia were selected as case and 62 singleton normotensive pregnant women were selected as control in their third trimester after meeting the inclusion criteria. Venous blood sample was withdrawn from each participant that was centrifuged to separate the serum and that was used to measure serum ferritin level. Serum ferritin was measured by chemiluminescent immunometric assay. All data were collected using a structured questionnaire and analyzed by using window based computer software devised with Statistical Packages for Social Sciences (SPSS, 22.0). Mean serum ferritin level among case and control was 136.40±117.13ng/ml and 65.38±43.77ng/ml respectively which was statistically significant (p=0.001; Odds ratio 10.47; 95% Confidence interval = 3.11-38.8). Patients with preeclampsia had higher serum ferritin level in contrast with normal pregnant women. Raised serum ferritin might have influence in the pathogenesis of preeclampsia.