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Association between Serum Ferritin and Preeclampsia.
M Nahar1, M S Uddin, B M Annur
1Dr Maksudun Nahar, Medical Officer, Department of Obstetrics and Gynaecology, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh;
Preeclampsia (PE) is a serious pregnancy complication. This study found significantly higher serum ferritin levels in preeclamptic women compared to healthy controls, suggesting a link between iron status and PE.
Area of Science:
- Obstetrics and Gynecology
- Clinical Biochemistry
Background:
- Preeclampsia (PE) is a common, serious obstetrical disorder with unclear pathophysiology.
- Serum ferritin, an indicator of iron status, is implicated in oxidative stress and lipid peroxidation relevant to PE.
Purpose of the Study:
- To investigate the relationship between serum ferritin levels and preeclampsia.
- To explore the potential role of iron status in PE pathogenesis.
Main Methods:
- A cross-sectional comparative study involving 62 preeclamptic and 62 normotensive pregnant women in their third trimester.
- Serum ferritin levels were measured using chemiluminescent immunometric assay.
- Data analyzed using SPSS software.
Main Results:
- Mean serum ferritin was significantly higher in the preeclampsia group (136.40±117.13 ng/ml) compared to the control group (65.38±43.77 ng/ml) (p=0.001).
- An odds ratio of 10.47 (95% CI: 3.11-38.8) indicated a strong association between higher serum ferritin and preeclampsia.
- Preeclamptic patients exhibited elevated serum ferritin levels relative to normal pregnant women.
Conclusions:
- Elevated serum ferritin levels are associated with preeclampsia.
- Raised serum ferritin may play a role in the pathogenesis of preeclampsia.
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