Expression of Ki-67 in Histopathologically Diagnosed Gastric Carcinoma Patients

Gastric Carcinoma, often known as Gastric Cancer, is the second leading cause of cancer-related deaths globally. Gastric cancer symptoms are virtually non-existent and by the time they appear, the disease has most likely spread. There is an urgent need to develop techniques for detecting stomach cancer that do not rely exclusively on histological findings. The Ki-67 labeling index analysis can show the tumor's aggressiveness. The investigation was carried out to assess the utility of Ki-67 as a tool for detecting stomach cancer. The aim of the study was to observe the expression of the Ki-67 expression in histopathologically diagnosed Gastric Carcinoma Patients. This cross-sectional analytical study was carried out in the Department of Pathology, Sir Salimullah Medical College, Dhaka, Bangladesh from July 2017 to June 2019. A total of 60 adults who were histopathologically diagnosed patients with gastric carcinoma in gastric endoscopic biopsies and resected samples. More than one-third of the patients (38.3%) belonged to the age group of 61-70 years. The age of the participants ranged from 40 years to 82 years. Fifty five percent (55.0%) were male and 45.0% were female, 63.3% of the cancers were in the pylorus region, 33.3% were in the body and 3.3% were in the cardiac end. Eighty percent (80.0%) of the participants had intestinal type of cancer and 20.0% had diffuse type. The mean Ki-67 labeling Index was 46.69±12.57 in Intestinal variety of gastric carcinoma 49.47±10.74 in diffuse variety, with no statistical significance between them. Fifty percent (50.0%) of the cancers were moderately differentiated, 36.67% were poorly differentiated and 13.33% were well differentiated. The Association between histopathological grading of gastric carcinoma and Ki-67 was found to be statistically significant. The tumor's growth is very variable. The Ki-67 labeling index demonstrates the proliferative activity of tumor cells. Ki-67 showed significant associations with the diagnosis and prognosis of gastric cancer.