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Understanding Left Ventricular Dysfunction in Liver Cirrhosis: Key Insights for Primary Care

S Panda1, A Singhai, B Shah

  • 1Dr Smritimayee Panda, Academic Senior Resident, Department of Endocrinology, SGPGI, Lucknow, India.

Mymensingh Medical Journal : MMJ
|December 31, 2025
PubMed

Insights

Cardiac dysfunction, specifically diastolic dysfunction, is common in liver cirrhosis. Its prevalence increases with liver cirrhosis severity, as indicated by Child-Pugh and MELD-Na scores, but not the cause.

Area of Science:

  • Cardiology
  • Hepatology
  • Medical Imaging

Background:

  • Cardiac dysfunction is a frequent complication of liver cirrhosis.
  • The link between cardiac dysfunction and liver cirrhosis severity requires further investigation.
  • Understanding this relationship is crucial for managing liver cirrhosis patients.

Purpose of the Study:

  • To investigate the association between liver cirrhosis severity and left ventricular diastolic dysfunction.
  • To determine if liver cirrhosis severity scores correlate with the presence and grade of diastolic dysfunction.

Main Methods:

  • A cross-sectional study involving 135 liver cirrhosis patients.
  • Assessment of liver cirrhosis severity using Child-Pugh Score and MELD-Na Score.
  • Evaluation of left ventricular diastolic function via 2D echocardiography.

Main Results:

  • Diastolic dysfunction was present in 55.6% of patients.
  • Higher MELD-Na scores (>19) and Child-Pugh Class C were associated with increased diastolic dysfunction prevalence.
  • The severity of diastolic dysfunction did not correlate with the cause of cirrhosis (alcoholic vs. non-alcoholic).

Conclusions:

  • Left ventricular diastolic dysfunction is prevalent in liver cirrhosis and its incidence rises with disease severity.
  • Child-Pugh and MELD-Na scores are useful indicators of diastolic dysfunction risk in cirrhosis.
  • The cause of cirrhosis does not influence the severity of diastolic dysfunction.

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