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Labetalol as a hypotensive agent in otological operations
Annales Chirurgiae Et Gynaecologiae
|January 1, 1979
Summary
Labetalol effectively lowers blood pressure during otological surgery. This alpha and beta adrenoceptor antagonist provides moderate hypotension without significant heart rate changes in patients.
Area of Science:
- Anesthesiology
- Pharmacology
- Cardiovascular Medicine
Background:
- Labetalol is a combined alpha and beta adrenoceptor antagonist.
- Its hypotensive effects in otological surgery require investigation.
Purpose of the Study:
- To evaluate the efficacy of labetalol as a hypotensive agent in otological operations.
- To determine the dosage and duration of labetalol's blood pressure-lowering effects.
Main Methods:
- A study involving 18 healthy patients undergoing otological procedures.
- Intravenous administration of labetalol at doses of 1.0 mg/kg and 2.0 mg/kg.
- Monitoring of systolic and diastolic blood pressure and heart rate.
Main Results:
- A single 1.0 mg/kg i.v. dose caused an 18% systolic and 8% diastolic decrease in blood pressure, peaking at 11 minutes and lasting 26 minutes.
- A single 2.0 mg/kg i.v. dose resulted in a 32% systolic and 20% diastolic decrease, peaking at 23.5 minutes and lasting 60.1 minutes.
- Moderate blood pressure reduction was observed without significant increases in heart rate or excessive hypotension.
Conclusions:
- Labetalol is a useful hypotensive agent for otological surgery.
- The drug demonstrates dose-dependent hypotensive effects with a favorable safety profile regarding heart rate and hypotension.