Related Experiment Video
Updated: Jun 12, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Polystyrene microplastics modulate the toxic effects of bisphenol A in the early stages of zebrafish development
Alessandra La Pietra1, Teresa Mobilio1, Gianluca Fasciolo1
1Department of Biology, University of Naples Federico II, Naples, Italy.
Abstract:
One of the characteristics of polystyrene microplastics (PS-MPs) is their hydrophobic surface, which allows them to carry other pollutants such as bisphenol A (BPA), known to be endocrine disruptor. This study investigated the co-exposure of 1 µm PS-MPs at 1.0 mgL-1 with BPA at 25.0 µM on zebrafish development. The results on the toxicity parameters showed that PS-MPs and BPA during co-exposure had antagonist effects reducing their effects compared to single exposure, in hatching, neurotoxicity and heart rate. This trend was confirmed by an improvement in the expression of developmental genes observed in the co-exposed group. However, in redox homeostasis analysis emerged that, when together, PS-MPs exacerbated the effects of BPA compared to single exposure in redox homeostasis analysis. The findings showed a dual role of PS-MPs in modulating the effects of BPA providing new information on the risk associated with their simultaneous presence in the aquatic environment.
Related Concept Videos
Prevention of Further Absorption of Poison
Plastic Behavior
Plasticizers
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Microbial Bioremediation of Pesticides
Bioplastics
Microbial Bioremediation of Plastics

