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Updated: Jan 7, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
Dynamic boronate ester crosslinked hyaluronic acid hydrogel patch enabling fast dissolution and rapid oral mucosal
Zhuohao Gu1, Jiafeng Wang1, Xinglei Shi1
1College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, PR China; Sino-Spain Joint Laboratory on Biomedical Materials (S2LBM), Research Institute for Biomaterials, Tech Institute for Advanced Materials, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, NJTech-BARTY Joint Research Center for Innovative Medical Technology, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, PR China.
Abstract:
Developing mucoadhesive and fast-dissolving drug delivery systems for oral mucosal applications remains a clinical challenge. Here, we report a pH-responsive phenylboronic acid-modified hyaluronic acid (HA-PBA) hydrogel film for efficient transmucosal delivery of Sumatriptan (Sum). The HA-PBA was synthesized via a one-step EDC/NHS-mediated amidation, with successful structural confirmation through 1H NMR, FT-IR, and UV-vis spectroscopy. The resulting hydrogel exhibited pH-dependent self-crosslinking via dynamic boronate ester bonds. Optimized films demonstrated excellent mucoadhesion under wet conditions and tunable mechanical strength. Drug-loaded films (BHA-SP) achieved homogeneous amorphous drug dispersion, confirmed by DSC, XRD, and SEM analyses. In simulated saliva, the films disintegrated within 5 s and released >80 % of the payload within 150 s. Ex vivo studies using porcine buccal mucosa revealed sustained, near zero-order permeation kinetics, while in vivo sublingual administration in rabbits achieved rapid absorption (Cmax 95.66 ng/mL at 30 min) and enhanced bioavailability compared to oral delivery. Cytocompatibility and in vivo oral ulcer healing evaluations demonstrated favorable biocompatibility and therapeutic efficacy. This work presents a promising platform for rapid, effective, and patient-friendly oral mucosal drug delivery.
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