Triglyceride-glucose index and risks of suicide mortality in young adults: a nationwide population-based study
Yu Ho Lee1, Kyungdo Han2, Hye Eun Yoon3,4
1Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea (the Republic of).
Background:
Suicide is a leading cause of death among young adults in South Korea. We investigated the association between triglyceride-glucose (TyG) index and suicide mortality in young adults.
Methods:
This nationwide study analysed data from 6 667 138 individuals aged 20-39 using the National Health Insurance Database. Participants were grouped into TyG index quartiles. The primary outcome was suicide mortality.
Results:
During a median follow-up duration of 10.7 years, 41 004 (0.6%) suicidal deaths occurred. The cumulative event rates for suicide mortality were highest among participants in TyG index quartile 4. Multivariable Cox analysis showed significant increases in the risks of suicide mortality in participants with TyG index quartile 4 compared with those in the low quartiles (adjusted HR 1.17, 95% CI 1.11 to 1.23, vs quartile 1; adjusted HR 1.15, 95% CI 1.10 to 1.20, vs quartile 1-3). The association between the TyG index and the risks of suicide mortality was positive and quasi-linear. Subgroup analysis showed a consistent trend of increasing HRs for suicide mortality with higher TyG index quartiles, with significant interactions between TyG index, sex and depression.
Conclusion:
TyG index can be useful in identifying young individuals at an increased risk of suicide mortality.
More Related Videos
Related Concept Videos
01:15Hypoglycemia and Glucagon
01:15Diabetes: Symptoms, Diagnosis, and Complications
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:24Obesity
01:24Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
01:19Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...