Home-based supervised exercise on metastatic cancer patients receiving oral targeted therapy: the AFSOS-Unicancer...

Area of Science:

• Oncology
• Exercise Science
• Patient Care

Background:

• The QUALIOR trial investigated a home-based supervised physical exercise program (SPEP) for metastatic cancer patients undergoing oral targeted therapies.
• Metastatic cancer patients on oral targeted therapies often experience significant fatigue and pain, impacting quality of life.

Purpose of the Study:

• To assess the feasibility of a 3-month home-based SPEP in patients with metastatic cancer receiving oral targeted therapies.
• To evaluate the impact of SPEP on fatigue and pain levels in this patient population.

Main Methods:

• A phase 2, multicenter trial randomized 112 patients (2:1) to either a 3-month home-based SPEP with a coach or a control group receiving adapted physical exercise recommendations via booklet.
• Feasibility was defined as the proportion of patients completing at least 50% of planned SPEP sessions.
• Fatigue and pain were secondary endpoints, measured using the Visual Analog Scale (VAS).

Main Results:

• 61% of patients in the SPEP arm completed at least 50% of the program, demonstrating feasibility.
• Median fatigue scores decreased from 4 to 3 in the SPEP group after 3 months, with sustained pain control.
• Patients in the SPEP arm showed significantly lower rates of high VAS fatigue at 3 months (27%) compared to the control arm (62%, p=0.004).

Conclusions:

• Home-based supervised physical exercise programs are feasible and beneficial for metastatic cancer patients on oral targeted therapies.
• SPEP can effectively mitigate cancer-related fatigue and maintain pain management, improving patient outcomes.